Hyperaldosteronism
Recent evidence in primary aldosteronism continues to favor definitive treatment for unilateral disease, with adrenalectomy providing stronger blood pressure, biochemical, and…
Asthma
This asthma update was dominated by high-significance evidence on phenotype-directed biologic care, with strong signals for exacerbation reduction in severe eosinophilic disease…
Crohn disease including Crohn colitis
Recent Crohn disease syntheses emphasize stronger evidence for targeted induction therapy, more sensitive small-bowel diagnostics, and tighter long-term risk stratification.…
Osteoporosis
This osteoporosis update was dominated by therapy optimization studies: anti-sclerostin antibodies and abbreviated romosozumab-to-denosumab sequencing both increased bone mineral…
Orthostatic hypotension
Recent orthostatic hypotension literature is dominated by Parkinson disease and neurogenic cohorts, where pooled data show OH in about one-third of patients and consistently link…
Bipolar disorder
Recent meta-analyses in bipolar disorder support short-term symptom improvement with asenapine for acute mania, benefit from collaborative chronic care models, and antidepressant…
Upper airway cough syndrome
Recent UACS literature remains dominated by diagnostic and phenotyping studies rather than high-volume interventional trials. Newer data suggest UACS is a common, often…
Lymphedema
Recent lymphedema evidence is centered on breast cancer populations and supports earlier, active prevention rather than limb-protection restrictions alone. Across meta-analyses…
Cervical cancer
Recent cervical cancer evidence supports a higher-value care model spanning prevention, systemic therapy, surgery, and surveillance. HPV vaccination continues to reduce high-grade…
Complications of transfusions
Recent evidence on complications of transfusion emphasizes reducing avoidable exposure and improving product selection rather than defaulting to broader transfusion use. Across…
Decisional capacity assessment
Recent evidence relevant to decisional capacity assessment is weighted toward surrogate decision support, end-of-life decision processes, geriatric workflow design, and clinician…
Actinic keratosis
Recent actinic keratosis evidence supports tailoring field therapy to durability goals, lesion burden, and patient context rather than using a single default approach. A 2025…
Acute and chronic sinusitis
Recent higher-significance evidence for sinusitis is concentrated in chronic rhinosinusitis, especially CRSwNP and postoperative management rather than uncomplicated acute…
Primary Headache Disorders
Recent evidence across primary headache disorders is most actionable in preventive care: a phase 4 trial supports eptinezumab plus brief education for chronic migraine with…
Pituitary Incidentaloma & Hyperprolactinemia
Current evidence suggests a rising detection and care burden for prolactin-related pituitary tumors, including incidentalomas, with meaningful shifts in incidence and case mix. In…
Adrenal Incidentaloma (Workup, surveillance)
Recent evidence supports a risk-stratified adrenal incidentaloma workflow: in unilateral MACS with hypertension, adrenalectomy improves blood-pressure control versus conservative…
Hyperparathyroidism (Primary, calcium workup)
Recent PHPT evidence supports a more nuanced calcium workup that goes beyond urinary calcium alone, especially for stone and operative risk decisions. Surgical management…
Polycythemia & Thrombocytosis Evaluation
Current evidence supports a tiered evaluation pathway for polycythemia and thrombocytosis that moves beyond isolated CBC thresholds to integrated clonal-risk assessment. Across…
Anemia of Chronic Disease & Workup
Current evidence supports a structured, mixed-etiology approach to anemia workup, especially when chronic inflammatory and iron-deficiency mechanisms overlap. In primary care and…
Fatty Liver Disease / MASLD (Non-pharmacologic management)
Recent evidence supports lifestyle-first MASLD care with emphasis on sustained exercise and long-term weight control, while also reinforcing cardiovascular risk integration.…
Gallstone Disease (Cholecystitis, biliary dyskinesia)
Current evidence reinforces early, definitive management for symptomatic gallstone disease while clarifying procedural risk tradeoffs. Delaying cholecystectomy is associated with…
Diverticular Disease (Acute diverticulitis management)
Recent evidence supports selective, risk-stratified management of acute diverticulitis rather than automatic escalation of antibiotics or surgery. For uncomplicated disease,…
Constipation (Chronic, secretagogues)
Evidence in this run supports a practical stepped approach for chronic constipation, combining targeted pharmacologic or adjunctive options with early response checks and dietary…
H. pylori (Test-and-treat, bismuth quadruple)
Recent evidence supports bismuth-based and other quadruple approaches as the practical backbone for H. pylori eradication in the setting of persistent resistance to legacy triple…
Celiac Disease (Screening, gluten-free diet)
Recent evidence reinforces that celiac disease screening and diagnosis should not depend on classic underweight phenotypes, particularly in pediatric care where normal or elevated…
Hepatitis B & C (Screening, direct-acting antivirals)
Recent real-world and policy data show that broad hepatitis C screening plus reliable confirmatory testing can be implemented at scale, while DAA therapy continues to deliver high…
HIV PrEP & PEP in Primary Care
Recent primary-care-focused evidence highlights that PrEP/PEP scale-up depends less on efficacy uncertainty and more on implementation quality, especially affirming care,…
Herpes Zoster & Post-Herpetic Neuralgia
Recent evidence for herpes zoster and post-herpetic neuralgia supports early risk-stratified prevention and aggressive pain control, with the strongest data coming from…
Skin Cancer Screening (Dermoscopy, High-Risk Patients)
Recent evidence reshapes primary care approaches to skin cancer screening. AI-powered diagnostic tools now match dermatologist-level accuracy for melanoma detection, offering PCPs…
Rosacea
Today's update reviews newer evidence relevant to Rosacea, with emphasis on what looks actionable in primary care.
Eczema & Atopic Dermatitis (Dupilumab, JAK inhibitors)
Atopic dermatitis evidence this year supports earlier targeted-therapy escalation for uncontrolled moderate-to-severe disease, with meaningful differences between biologic and JAK…
Psoriasis & Psoriatic Arthritis (Biologics in primary care)
Recent psoriasis/PsA evidence reinforces earlier use of high-efficacy targeted therapies and tighter phenotype-based treatment selection. New randomized and network evidence…
Neuropathic Pain (Gabapentinoids, SNRIs, topicals)
Recent high-level evidence in neuropathic pain emphasizes selective use of gabapentinoids and stronger integration of nonpharmacologic care. Large trials and meta-analyses show…
Chronic Pain Management (Multimodal, opioid sparing)
New evidence relevant to multimodal, opioid-sparing care emphasizes that primary-care-centered medication pathways, implementation quality, and coordinated follow-up can drive…
Opioid Use Disorder & Buprenorphine in Primary Care
Recent evidence supports expanding office-based treatment for opioid use disorder in primary care while focusing on pragmatic delivery choices that improve access and continuity.…
Alcohol Use Disorder (Naltrexone, Acamprosate, brief interventions)
Recent evidence supports scaling pragmatic, low-friction interventions for unhealthy alcohol use in primary and acute care, with stronger outcomes when behavioral treatment is…
Smoking Cessation (Varenicline, combination NRT)
Recent RCT and meta-analytic evidence supports combining pharmacotherapy with behavioral support to improve smoking cessation outcomes in primary care populations. Highest-yield…
Insomnia (CBT-I, pharmacotherapy safety)
Recent high-level evidence reinforces CBT-I (including digital formats) as first-line care for chronic insomnia, with measurable gains in remission and sustained benefit. For…
Sleep Apnea (OSA screening, CPAP adherence)
Recent high-level evidence reinforces OSA as a cardiovascular risk condition where treatment intensity and adherence materially influence outcomes. In primary care, the biggest…
Overactive Bladder & Urinary Incontinence
Recent evidence supports a conservative-first, cognition-aware approach for overactive bladder and urinary incontinence in primary care. Behavioral therapy and pelvic floor…
Benign Prostatic Hyperplasia (Alpha-blockers, 5-ARIs)
Recent BPH evidence supports risk-stratified medication escalation rather than symptom-only treatment. Guideline updates reinforce pairing alpha-blockers with 5-ARIs in men at…
Erectile Dysfunction (Cardiovascular risk marker, PDE5i)
Recent evidence reinforces erectile dysfunction as both a treatable symptom and a cardiovascular risk signal in primary care. High-value updates support a structured first-line…
Venous Thromboembolism Prophylaxis & DOACs
Recent high-evidence publications support simplifying anticoagulation in stable CAD, favoring DOAC-centered pathways for many VTE/AF scenarios, and reinforcing risk-stratified…
Peripheral Artery Disease (Claudication, ABI screening)
Recent PAD evidence suggests three practical shifts for primary care: stronger use of scalable activity interventions when supervised exercise is inaccessible, tighter medication…
Chronic Fatigue & Fibromyalgia Management
Today's evidence set emphasizes multimodal fibromyalgia care, with the strongest practice signals in sleep-targeted therapy, structured nonpharmacologic programs, and scalable…
Gout & Hyperuricemia (Acute vs Prophylaxis)
Today’s evidence set included recent RCTs, meta-analyses, and guideline updates relevant to gout and hyperuricemia. The strongest practice signals were around treat-to-target…
Urinary Tract Infections & Prostatitis (Resistance)
Recent evidence in resistant UTI/prostatitis highlights where empiric choices should narrow and where culture-guided adjustments are most likely to change outcomes in primary care.
Immunizations: Adult/Elderly (RSV, Pneumococcal, Shingles)
Recent evidence supports aggressive adult respiratory and zoster immunization in primary care, especially for older adults and patients with cardiopulmonary or immune-mediated…
Cancer Screening: Lung (LDCT eligibility)
Recent randomized evidence suggests the biggest practice lever in lung cancer screening is integrating high-intensity tobacco treatment directly into LDCT workflows. Digital…
Cancer Screening: Prostate (PSA shared decision making)
Recent prostate-screening evidence supports risk-stratified pathways (PSA density, MRI-first, and multi-marker tests) that preserve detection of clinically significant disease…
Cancer Screening: Breast & Cervical (Guidelines)
Recent breast and cervical screening evidence emphasizes risk-stratified implementation over one-size-fits-all pathways. In breast screening, high-impact trials support…
Cancer Screening: Colorectal (Cologuard vs Colonoscopy)
New colorectal screening evidence favors strategy selection by participation, risk, and local capacity rather than one universal pathway. Randomized data continue to show a…
Hypothyroidism & Thyroid Nodule Management
Recent evidence supports a more selective treatment strategy for mild subclinical hypothyroidism in older adults while reinforcing earlier levothyroxine optimization in…
Iron Deficiency Anemia & Microcytic Anemias
Recent evidence supports practical shifts in primary-care iron-deficiency management: alternate-day oral iron can preserve efficacy while improving tolerability, and earlier…
Irritable Bowel Syndrome (IBS-C vs IBS-D treatments)
Recent IBS evidence supports more subtype-specific management in primary care: dose-aware pharmacologic choices for IBS-C and broader use of accessible behavioral therapy formats.…
Gastroesophageal Reflux Disease (GERD, PPI safety)
Recent GERD evidence supports a stepwise strategy that can reduce unnecessary PPI intensification while identifying where newer acid suppressants may improve short-term healing.…
Migraine & Tension Headaches (CGRP inhibitors)
Across recent high-evidence studies, CGRP-targeted therapies and related migraine strategies continue to show clinically meaningful reductions in migraine burden for selected…
Dementia & Mild Cognitive Impairment (Screening, AD)
New high-yield evidence supports blood-based Alzheimer biomarker use as a practical diagnostic triage step, while reinforcing that test performance is assay-specific and must be…
Depression & Anxiety in Primary Care (SSRIs/SNRIs)
Recent high-yield evidence reinforces SSRIs/SNRIs as effective first-line pharmacotherapy for anxiety/depression while highlighting two practice-critical safeguards: early…
Osteoporosis (FRAX, Bisphosphonates, screening)
Recent high-value osteoporosis evidence supports tighter risk-stratified care in primary care: use FRAX plus BMD to target treatment, keep bisphosphonates first-line for most…
Low Back Pain (Acute vs Chronic, imaging guidelines)
Recent high-evidence studies support a stronger primary-care shift toward early active self-management for acute low back pain and multimodal biopsychosocial care for chronic low…
Osteoarthritis (Knee/Hip, conservative vs surgical)
Updated high-evidence osteoarthritis literature supports a stepwise strategy: exercise-centered conservative care first, targeted adjuncts when function remains limited, and…
Chronic Kidney Disease (CKD staging and progression)
Recent high-evidence CKD updates support earlier risk-targeted intervention in primary care, especially around anemia pathways and cardiometabolic therapy selection. KDIGO 2026…
Asthma Management (GINA guidelines, SMART therapy)
Recent high-evidence asthma updates reinforce a major primary-care shift: avoid SABA-only rescue and prioritize anti-inflammatory reliever strategies, especially ICS-formoterol.…
Atrial Fibrillation: Anticoagulation & Management Updates
This update highlights critical evidence on DOAC safety and efficacy in complex populations, including those with frailty, ICH history, and hypertrophic cardiomyopathy. New…
Congestive Heart Failure (HFpEF vs HFrEF management)
Recent guidelines and trials emphasize the expanding role of GLP-1 agonists (semaglutide, tirzepatide) and MRAs (finerenone) in HFpEF, alongside the consolidated 'four pillars'…
Coronary Artery Disease & Antiplatelet Therapy
**Date:** Friday, February 6, 2026
Hypertension (JNC-8 vs SPRINT vs ACC/AHA)
**Monday, February 3, 2026**